Abstract
Bioactivity-guided fractionation of Notopterygium forbesii has resulted in the isolation of one new coumarin glycoside and one new phenethyl vanillate, together with seventeen known compounds. The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their binding affinities to the opioid and dopamine receptors, and falcarindiol showed weak binding affinities to opioid receptors and moderate affinity for D1 receptor (K(i)=192+/-6 nM).
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Coumarins / chemistry*
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Coumarins / isolation & purification
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Diynes / chemistry
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Fatty Alcohols / chemistry
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Humans
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Protein Binding
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Receptors, Dopamine / metabolism*
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Receptors, Opioid / metabolism*
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Spectrum Analysis
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Vanillic Acid / chemistry*
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Vanillic Acid / isolation & purification
Substances
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Coumarins
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Diynes
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Fatty Alcohols
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Glycosides
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Receptors, Dopamine
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Receptors, Opioid
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falcarindiol
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coumarin
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Vanillic Acid